You might be curious about RAD-140, also known as Testolone. It’s a compound gaining attention. This article explores what research tells us about it.
RAD-140 is a selective androgen receptor modulator, or SARM. These compounds are designed to interact with androgen receptors in the body. Think of androgen receptors as locks. SARMs are like keys that can turn these locks.
Different SARMs may affect different tissues. This is how they earn the “selective” label. The goal is to activate certain effects without triggering others. This selective action is the theoretical advantage.
Preclinical Research on RAD-140
Much of the early research on RAD-140 occurred in laboratory settings. This includes studies on cells and animals. These studies help scientists understand how a compound might behave.
Understanding Anabolic Effects in Preclinical Models
One area of focus is muscle growth. Preclinical studies have explored RAD-140’s ability to affect muscle tissue. Researchers look for changes in muscle mass and protein synthesis.
Animal Models and Muscle Development
Animal research, such as studies in mice, has examined RAD-140’s impact. Scientists observe effects on muscle size and strength in these models. This helps form hypotheses about potential human effects. However, results in animals do not always translate to humans.
Bone Health in Preclinical Research
Bone density is another area of interest. RAD-140 has been studied for its potential effects on bone. Research in 2025 explored RAD-140 in combination therapies for muscle growth and bone density. This work is ongoing. Scientists look at bone mineral density and microarchitecture.
Investigating Bone Microarchitecture
Preclinical studies aim to understand how RAD-140 might influence bone structure. This involves examining the intricate details of bone tissue. Such research builds a foundational understanding.
Safety Considerations and Emerging Concerns
As research progresses, safety becomes a critical aspect. Preclinical data can sometimes flag potential risks. These findings guide further investigation.
Preclinical Data on Potential Harms
Early research can identify compounds that might cause harm. A 2023 mouse study indicated that RAD-140 increased frailty and mortality risk in young female mice. This study also noted a reduction in adaptive potential. No strength improvements were observed. This suggests potential harm where sarcopenia treatment is a goal.
Liver Toxicity in Animal Models
Some preclinical work has investigated liver function. Researchers monitor liver enzymes and cellular health. This helps identify potential hepatotoxic effects.
Human Evidence for RAD-140
It is crucial to distinguish between preclinical findings and human evidence. Currently, strong, robust human clinical trial data on RAD-140 is limited. Scientific understanding in humans is still developing.
Lack of Clinical Trials
Formal clinical trials designed to evaluate RAD-140’s efficacy and safety in humans are not widely available. Regulatory bodies like the FDA have not approved RAD-140 for any medical use. This means its health benefits and risks in people are not well-established.
Case Reports and Anecdotal Information
Some information comes from case reports. One case report described severe liver injury in a bodybuilder using RAD-140. This included hyperbilirubinaemia and cholestatic hepatitis. The reaction was considered probable. It worsened initially and then resolved after discontinuing the compound.
Regulatory Stance and Warnings
Regulatory agencies have taken notice of products containing RAD-140. In December 2025, the FDA issued a warning letter to a company selling unapproved RAD-140 products. The company claimed muscle gains, strength enhancement, and neuroprotection. The FDA highlighted potential risks such as liver toxicity, heart attack, and stroke.
Regulatory Status and General Reviews
<?xml encoding=”UTF-8″>
| Metric | Value | Details |
|---|---|---|
| Chemical Name | RAD-140 | Also known as Testolone |
| Type | SARM (Selective Androgen Receptor Modulator) | Non-steroidal compound |
| Molecular Formula | C20H16ClN5O2 | Represents the chemical composition |
| Half-life | 16-20 hours | Duration RAD-140 remains active in the body |
| Common Dosage | 10-30 mg per day | Typical range used in research and supplementation |
| Primary Effects | Muscle growth, fat loss | Promotes anabolic activity selectively in muscle and bone |
| Binding Affinity | High | Strong affinity for androgen receptors |
| Administration | Oral | Usually taken in capsule or liquid form |
| Side Effects | Possible testosterone suppression, mild liver toxicity | Reported in some users, varies individually |
| Research Status | Investigational | Not approved for human use by regulatory agencies |
The regulatory landscape for compounds like RAD-140 is complex. These substances often appear outside of approved medical channels.
Unapproved Status in Major Markets
RAD-140 is not approved by major regulatory bodies for human consumption. This includes the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). It also lacks approval from Australia’s Therapeutic Goods Administration (TGA).
Promotion vs. Evidence
You may see RAD-140 promoted online and in certain communities. It is often marketed for lean muscle, strength, and recovery. However, these claims are not supported by regulatory approval. General reviews reiterate that RAD-140 carries hepatotoxicity risks. The TGA/FDA have not approved it.
FAQs
What is RAD-140 Testolone?
RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) designed to mimic the effects of anabolic steroids. It is primarily used to increase muscle mass and strength without the severe side effects associated with traditional steroids.
How does RAD-140 work in the body?
RAD-140 selectively binds to androgen receptors in muscle and bone tissues, stimulating protein synthesis and muscle growth. Unlike anabolic steroids, it targets these tissues specifically, which helps reduce unwanted side effects on other organs.
What are the common uses of RAD-140?
RAD-140 is commonly used by athletes and bodybuilders to enhance muscle growth, improve strength, and aid in fat loss. It is also being researched for potential therapeutic uses, such as treating muscle wasting diseases and osteoporosis.
Is RAD-140 legal and safe to use?
The legality of RAD-140 varies by country. It is not approved by the FDA for human consumption and is often sold as a research chemical. Safety data is limited, and potential side effects may include hormone imbalances, liver toxicity, and cardiovascular issues. It is important to consult a healthcare professional before use.
What are the potential side effects of RAD-140?
Possible side effects of RAD-140 include testosterone suppression, mood changes, headaches, nausea, and increased liver enzymes. Long-term effects are not well studied, so caution is advised when considering its use.
