Natoli Engineering Company, Inc. Tablet Compression Tooling, Press Punches and Dies

Delivering Unparalleled Quality.

As a leading manufacturer for more than 35 years, Natoli Engineering Company continues to deliver high-quality tablet compression equipment and support to the pharmaceutical, veterinary, industrial, confectionary, and nutritional product manufacturers across the globe.

Natoli’s dedication to innovation, quality, and excellence has propelled them to the forefront of the tablet compression industry. Natoli has achieved international recognition for value, performance, and dependability.

Natoli are offering a 2-day course on the "Basics of Tablet Manufacturing and Troubleshooting" based at their Technical Training Centre in St Charles, Missouri.

Punches and Dies

Tablet Press Punches and DiesNatoli manufactures a variety of tablet compression tooling, including carbide-tip, multiple-tip, single-tip, small-tip, rotating heads/tips, IMA Comprima tooling, and a vast selection of 3-D exotic shape punches and dies. Natoli’s strict steel quality assurance systems set the standard for the tablet compression tooling industry.

Before it can be cut, incoming steel undergoes rigorous laboratory testing to verify its chemistry, consistency and cleanliness. After steel quality has been confirmed, Natoli's Computerized Vacuum Internal Quench Heat-Treating System guarantees product consistency.
Maintaining highly efficient and structured manufacturing facilities with a one-year inventory of steel ensures consistent, quality punches and dies regardless of industry demand and availability. All of Natoli’s tablet compression tooling is available for worldwide delivery.

Tablet Presses

NP 500 Tablet Press

The Natoli NP-500 Series is a heavy-duty, double-sided rotary tablet press available in semi-automatic and automatic models. The NP-500 Series tablet press was devised for compression of tablets needing extra fill and extended dwell time, and is ideal for high compression ratio products. Combining remarkable tablet production, automation, and dependability with lower servicing costs, the NP-500 is one of the most economically efficient tablet presses on the market.
Ideal for pharmaceutical laboratory research and development, Natoli offers the single station, manually operated NP-RD10 tablet press that permits independent control of both tablet hardness and weight to meet tablet production requirements and specifications. The NP-RD10 fits on bench top areas and is also available in a semi-automatic model.
Natoli also offers the NP-100 – a double-sided, high-output BB type tablet press – for use with ¾” tooling, the NP-200 – a single-sided D3 type tablet press – for use with 1” tooling, and the NP-300 – a single-sided D3 type tablet press – for use with 2” tooling. For more information and specifications on Natoli’s entire line of tablet presses, please visit their website or contact them directly.

Tablet Press Replacement PartsTablet Press Replacement Parts, Turrets, and Refurbishing Services

Natoli maintains over 300,00 tablet press replacement parts and turrets for nearly every press type and model. Their expertise allows them to critically analyze original equipment manufacturer’s (OEM) parts to uncover potential flaws. Their redesigns produce a precision replacement part that outlasts and outperforms OEMs.

Natoli’s experienced and knowledgeable parts experts provide exceptional customer service and support for clients’ needs. Natoli also offers tablet press refurbishing of unsurpassed quality for various tablet press types, leaving them looking and running better than new.

Tablet Compression Accessories Catalog

Natoli's Tablet Compression Accessories Catalog is the most comprehensive catalog available today that solely supports the tablet compression industry.

This catalog serves as a valuable resource with over 150 pages of product, equipment, and reference on set-up, inspection, maintenance, tablet analysis and much more. All products listed in the catalog are available for worldwide shipment.

Tablet Compression Tooling Management System

TM-II LVS Punch Inspection Device

Natoli’s TM-II Tool Management software, combined with the Laser Vision System (LVS) punch inspection device, provides critical tooling data faster and easier than any other system.

TM-II software features a database to help you manage tooling statistics associated with inspections, measurements, suppliers, purchase orders, wear analysis, tablet production history, drawings, steel and machine type, storage locations, embossing, and more.

Technical Training

Natoli Technical Training Center

Whether you want to improve your skills, production processes, or keep up with industry trends, Natoli's Technical Training courses help you achieve your goals. Their courses feature hands-on training, theories, processes, and real-world scenarios—in just a matter of days you will be more productive and embracing new technology standards.

Natoli's Technical Training Center is the first non-commercial training center exclusively dedicated to educating the tablet compression industry. Natoli's state-of-the-art training center, developed with over 35 years of industry experience, is the most significant tablet compression training center in the United States. Top industry professionals from around the world and Natoli's own highly experienced staff deliver powerful training that cannot be found in textbooks.

Natoli training courses focus on top industry issues such as tablet technology; tablet compression tooling standards and options; FDA GMP and compliance; tablet press set-up and maintenance; tablet manufacturing; tablet coating, mixing, blending, excipient choices, and more.


Natoli’s headquarters is strategically located in one of the Midwest’s finest progressive industrial parks, Missouri Research Park of St. Charles, MO. The 120,000 square-foot campus includes administrative, manufacturing, refurbishing, training, and teleconferencing facilities.

Revolutionizing Worldwide Standards

Carmelo Natoli built Natoli Engineering Company around his simple philosophy to “supply a quality tool at a fair price with expedited service.” This philosophy is the cornerstone of Natoli’s success and will continue into the future. Natoli looks forward to the opportunity to help your business grow and succeed.


Contact this Supplier

Receive Pharmaceutical International Newsletter

Natoli Engineering Company, Inc.

Research Park Circle
Saint Charles, Missouri, 63304, USA

Tel: +1 636 926 8900