Farfield Group Ltd - Dual Polarisation Interferometry, Pharmaceutical Screening, Interfacial Studies
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Farfield is an innovator and global supplier of analytical instruments and contract research services, addressing the metrology needs of Biophysics and Surface Science research and development. These disciplines provide the most demanding measurement challenges facing nanotechnology research.
In Biophysics, Farfield's proprietary technology is capable of revealing the intimate and complex relationship between structural change and function in biological molecules in real time, at market-leading levels of sensitivity and resolution.
In Surface Science Farfield's measurement solutions offer the physical scientist, insights into the structural and functional behaviour of biomolecules, surfactants, polymers and fine chemicals on a range of surfaces relevant to FMCG sectors.
Dual Polarisation Interferometry: Protein Conformation Analysis
The AnaLight® Bio200 utilises Farfield's Dual Polarisation Interferometry (DPI) technology. Controlled sample transport introduces the sample to the AnaChip™ waveguide surface, enabling data acquisition and analysis. The technique produces high-resolution, quantitative structural measurements in real time, comparable with techniques such as NMR spectroscopy and circular dichroism (CD).
A range of prepared AnaChip™ surfaces and reagent kits is available to suit all applications which include: antibody/antigen interactions; isoform-specific protein-protein interactions; lipid/membrane protein interactions, protein conformation analysis and protein/metal ion studies, ie. conformational change in prion protein challenged with various metal ions.
Sample Delivery for Pharmaceutical Screening
The AnaLight® BioFlex offers automated sample delivery to 50-vial, 96-well and 384-well plate formats, allowing the operator to scale up their research and development. User-friendly method scripting allows unattended operation with the benefit of optional manual intervention during runs.
Applications include: lead discovery; lead optimisation; pharmaceutical screening; identification of drug targets and drug candidates; development of diagnostic assays; ligand binding studies and determination of specific and non-specific binding in drug candidate investigations. For example, DPI has been used to investigate conformational change in MAP kinase (implicated in cancer, inflammation and obesity) in response to agonists, antagonists and non-specific binders.
Molecular Microscope: Interfacial Studies
The AnaLight® Nano200 Molecular Microscope is a manual DPI system whose quantitative structural measurements agree well with methods such as ellipsometry and neutron reflection. Controlled micro-fluidic injection transports the sample over the AnaChip™ waveguide surface, enabling data acquisition and analysis. A range of prepared AnaChip™ surfaces and reagent kits is available to suit all applications which include: interfacial studies, membrane studies; polymers, surfactants and their interactions; biocompatibility, eg. deposition of proteins and peptides onto wound dressings, dental implants and contact lens material; the analysis of lipid bilayers and liposomes and their interactions with other biomolecules, eg. the disruption of immobilised liposomes by melittin.
Automated Sample Delivery
The AnaLight® NanoFlex is an automated sample delivery system compatible with 50-vial, 96-well and 384-well plate formats, allowing high productivity research and development. The device offers unattended operation and optional user intervention.
The AnaLight® NanoFlex has proved invaluable for customers in the FMCG sector, with quantitative, real-time data producing accurate results allowing rapid validation of product claims. It has been used to study surfactant formulation behaviour, oral hygiene, cosmetic products etc. and hence speed up the translation of research ideas into marketable products. Farfield's ability to analyse optical anisotropy (birefringence) allows DPI to provide accurate analysis of ordered systems such as lipids, membrane proteins and their interactions.
Contact:
Robert C Hutton PhD
Sales and Marketing Director
Farfield Group Ltd.
Farfield House
Southmere Court
Electra Way
Crewe Business Park
Crewe
Cheshire
CW1 6GU
United Kingdom
Mobile: +44 7738 171457
Tel: +44 870 950 9717
Fax: +44 870 950 9718
Dual Polarisation Interferometry
- Dual Polarisation Interferometry (DPI) technology, European Seminar Tour »
Walis Jones and Arun Harish of Farfield Group Ltd have recently completed a tour of a number of Institutions in Europe to promote Farfield’s unique Dual Polarisation Interferometry (DPI) technology and its applications across a range of Biophysical disciplines. - Dual Polarisation Interferometry: Farfield Expands International Patent Portfolio »
Five New Patents Granted, Building on a Portfolio of Over 50 Applications Pending
Scientific Discovery
- Farfield Celebrates Ten Years of Excellence in Scientific Discovery »
We at Farfield Group Limited are proud to celebrate our 10 year anniversary.
Biophysics Interferometry Systems
- Farfield AnaLight® Systems for Biophysics »
AnaLight® Systems for Biophysics bring Farfield's revolutionary Dual Polarisation Interferometry (DPI) technology into instrument formats to suit a range of classical biophysics applications in basic research, drug discovery and drug and assay development.
Northwest Biotechnology Awards
- Farfield Group named as Biotechnology Company of the Year »
Farfield Group Limited (Crewe, United Kingdom) was delighted to be named as “Northwest Biotechnology Company of the Year” at the recent Annual Northwest Biotechnology Awards dinner organised by Bionow, the Northwest Regional Development Agency’s (NWDA) biotechnology cluster support group.
Packaged Nanometrology Solutions
- World's First Commercially Packaged Nanometrology Solution Targeted at FMCG Producers »
Bench-top solution delivers product claim verification, shorter product lead times, reduced manufacturing costs and environmental benefits.
Nano-scale Measurement
- Farfield Group Ltd Appoints Malvern Instruments As Exclusive Distributor Of Its AnaLight® Products In The United States, South And Central America »
Farfield’s AnaLight® Instruments for molecular and nano-scale measurements complement Malvern Zetasizer Nano capabilities
Biomolecular Structure Functions
- Biomolecular Structure-Function Measurement »
"Accessible, Quantitative Biomolecular Structure-Function Measurement" with the AnaLight® Bio200
Membrane Protein Function
- Strategic Development Partnership between Farfield Group Ltd and Monash University »
Farfield Group Limited forms strategic partnership to investigate membrane protein function.
Molecular Structure Measurement
- Farfield Group Ltd Expands Product Portfolio for FMCG Applications »
New Cellulose AnaChip™ provides detailed information on surface and interfacial behaviour for fabric care and paper technologists
International Portfolio
- Farfield Expands International Patent Portfolio »
Five New Patents Granted, Building on a Portfolio of Over 50 Applications Pending.
Industry News
- Dr Simon Carrington is International Business Director of the Year 2007 »
More than 700 of the North West's business elite gathered together at the IoD North West Director of the Year Awards where Dr Simon Carrington of Farfield Group Ltd. won the coveted Institute of Directors title “International Business Director of the Year”.
Dual Polarisation Interferometry
- Real Time measurement of Protein Structure: Dual Polarisation Interferometry »
Proteins, the building blocks of life, are diverse and complex molecules whose correct function is essential to all biological processes and whose malfunction lies at the heart of almost every disease. - AnaLight® Dual Polarisation Interferometer »
China opens the door to AnaLight® dual polarisation interferometry technology
Scientific Recruitment
- Scientific Recruitment: Career Opportunities at Farfield Group Ltd »
Farfield Group Ltd have career opportunities for sales professionals and product support specialists to sell analytical instruments
Analytical Microsystems
- Analytical Microsystems and Biomolecular Receptors Research Fellowship Opportunity »
Research fellowship opportunity for a 2 year project on scanning analytical microsystems based on biomolecular receptors
Dual Polarisation Interferometry
- AnaLight 4D Dual Polarisation Interferometer »
Farfield introduce the new AnaLight 4D dual polarisation interferometer for biophysical characterisation and life science research - Biophysical PhD Fellowships Using IAsys® Biosensors and AnaLight® Dual Polarisation Interferometry »
Marie Curie Short Term Early Stage Training Fund Fellowship Opportunities in the UK
Hepatitis Diagnosis
- Viral Hepatitis Diagnostic Test »
Farfield Group Ltd Announces Pan-European Collaboration on Hepatitis Diagnostic Test
Pharmaceutical Product Specialists
- Farfield Adds Strength to its Sales Team »
Farfield appoints Dr Usha Devi and Dr Tim Fagge as Product Specialists
