SubscribePro-OpioMelanoCortin (POMC) has long been a molecule of fascination, being the prime precursor to a multiplicity of biologically-active peptides such as ACTH, ß-Lipotrophin (ß-LPH), ß-endorphin, Alpha-Melanocyte Stimulating Hormone (a-MSH) and more.
It is also a very well-conserved molecule, being found in most vertebrates studied, including those "living fossils", the lungfish.
The OCTEIATM POMC ELISA measures "ACTH precursors" (i.e. measures both POMC and pro-ACTH equally) in plasma samples, and provides an invaluable tool to researchers investigating pituitary function and the hypothalmic-pituitary-adrenal axis.
The relative proportions of precursors: ACTH is of interest in the etiology of Cushings syndrome and in precursor processing in tumors of different types and origins. Potential roles in obesity/satiety and hyperpigmentation are also of interest. The diversity of potential roles continues to grow - there is little doubt that this product will meet the hitherto unaddressed needs of many researchers!
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