SubscribeSolvias AG discuss new innovations in process analytical technology (PAT) and examine the benefits of using near infrared (NIR) spectroscopy
Relying solely on pressure gauges and thermometers to monitor pharmaceutical manufacturing only provides you with part of the picture. Innovations in process analytical technology (PAT) can provide you with a wealth of information that can give you more accurate information throughout the manufacturing process and help you improve your quality control.
Process Analytical Technology - PAT
PAT systems have been a hot topic over the past few years because of their ability to provide quality information in real time by combining traditional process monitoring with material properties and advanced data analysis techniques. However, not all Process Analytical Technology systems are the same, especially when it comes to the utilization of in-line testing systems. One of the most versatile and reliable in-line process monitoring tools is near infrared (NIR) spectroscopy.
The push for NIR to play a strong role in PAT within the pharmaceutical industry gained more impetus earlier this year, when in July 2007, the United States Pharmacopeia (USP) announced the release of its revised General Chapter on NIR spectroscopy. This new chapter discusses the various pharmaceutical applications of NIR in current use, and highlights the many potential benefits of incorporating NIR into PAT schemes. The USP notes that the benefits of NIR include:
- Nondestructive and noninvasive in-line sampling• Rapid process quantification
- Versatility and customizability
- Continuous monitoring
- Shortened manufacturing cycles
- Reduced need for routine off-line testing
Near Infrared Specroscopy - NIR
Some pharmaceutical organizations have already taken advantage of near infrared spectroscopy in PAT and its use is expected to grow dramatically over the next few years.
Examples of pharmaceutical applications of NIR to PAT include:
- Rapid determination of reaction endpoints
- Monitoring concentrations of hazardous materials
- On-line determination of quality attributes previously only measurable off-line
- Process control
For a number of years, Solvias AG has been active in developing NIR-PAT solutions for the pharmaceutical industry, utilizing NIR to provide real-time analytical results to meet specific customer needs. Not only does Solvias have the necessary know-how to deliver customized PAT solutions, but Solvias also manufactures its own NIR probes and offers a wide range of sensors to match the demands of the various processes used in the pharmaceutical industry.