SubscribeOver the past ten years, OctoPlus has successfully formulated every kind of injectable compound, specialising in biopharmaceuticals.
Although formulation development of a biopharmaceutical is in many aspects not different from formulating a conventional low molecular weight compound, there are a number of features to a biopharmaceutical that require special consideration.
The physical and chemical stability of proteins is weak and conditions that accelerate degradation reactions such as exposure to oxygen, light, heat, shear and the presence of organic solvents or surfaces should be avoided during formulation, storage and administration of the biopharmaceutical.
It has been demonstrated that even labile products can be stored as aqueous solutions for 2 years at refrigerator temperatures. This shows that by choosing the right formulation, even these delicate biopharmaceuticals may retain their activity for years.
The majority of biopharmaceutical proteins and peptides currently on the market are stabilized by freeze drying the product in the presence of lyoprotectants. OctoPlus's production facilities offer several freeze drying options.
OctoPlus has succesfully applied its expertise in formulation development, analysis and manufacturing of a large number of different biopharmaceutical products. Its proven track-record in this specialized area combined with a knowledgeable and skilled workforce makes OctoPlus the partner of choice for cost-effective and fast formulation development of biopharmaceuticals, meeting the necessary regulatory requireme
Partner with OctoPlus
OctoPlus is dedicated to pharmaceutical innovation of drug compounds, both by using proprietary and non-proprietary technologies and knowledge. We have a partnership-minded attitude and work for our sponsors in a professional and service-oriented way. Please feel free to contact us and discuss your needs.
